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推荐产品
更多>>
Cat#
产品名称
信息描述
CC1303
Barasertib (AZD1152-HQPA)
Barasertib (AZD1152-HQPA)是一种高度选择性的
Aurora B
抑制剂，无细胞试验中
IC50
为0.37 nM，作用于Aurora B比作用于Aurora A选择性高3700倍左右。
CC2425
Baicalin
Baicalin 是一种脯氨酰肽链内切酶抑制剂，影响GABA受体。
CC8528
AZD9496
AZD9496是口服的
雌激素受体
抑制剂，在临床肿瘤模型中，能阻止ER阳性以及携带ESR1突变的乳腺肿瘤的生长。
CC7311
Batimastat (BB-94)
Batimastat (BB-94)是一种有效的，广谱
matrix metalloprotease (MMP)（基质金属蛋白酶）
抑制剂，作用于MMP-1， MMP-2， MMP-9， MMP-7和MMP-3，
IC50
分别为3 nM， 4 nM， 4 nM， 6 nM和20 nM。
CC1569
Bafilomycin A1(Baf-A1)
Bafilomycin A1(Baf-A1)是一种液泡
H
+
-ATPase
抑制剂，
IC50
为0.44 nM。
CC7162
BAY-61-3606
BAY-61-3606是一种有效的、选择性的
Syk激酶
抑制剂，Ki为7.5 nM。
CC3007
Baricitinib (LY3009104, INCB028050)
Baricitinib (LY3009104, INCB028050)是一种选择性
JAK1
和
JAK2
抑制剂，无细胞试验中
IC50
分别为5.9 nM和5.7 nM，比作用于JAK3和Tyk2选择性高70和10倍左右，对c-Met和Chk2没有抑制作用。Phase 3。
CC8608
BAY-876
BAY-876是有效的、选择性的
GLUT1
抑制剂（IC50=0.002 μM），对GLUT1的选择性比对GLUT2, GLUT3和GLUT4的选择性高100倍。
CC3213
Azilsartan Medoxomil
Azilsartan Medoxomil是一种有效的
angiotensin II type 1 (AT1) receptor（血管紧张素II 1型受体）
拮抗剂，抑制
RAAS
比作用于AT2选择性高10，000倍以上，用于治疗高血压。
CC1827
（6-）ε-Aminocaproic acid
（6-）ε-Aminocaproic acid是赖氨酸的衍生物和类似物。
CC2708
Azelastine HCl
Azelastine HCl是有效的，第二代选择性组胺拮抗剂。
CC2284
Bazedoxifene HCl
Bazedoxifene HCl是一种新型非甾类基于吲哚的雌激素受体调节剂(SERM)，靶点有
ERα
和
ERβ
，
IC50
分别为23nM和89nM。
CC8896
Lacosamide
Lacosamide (Vimpat; Erlosamide)可作用于部分发作的癫痫和糖尿病引发的神经性疼痛。
CC7335
BAF312 (Siponimod)
BAF312 (Siponimod)是一种二代S1P受体调节剂，选择性作用于
S1P1
和
S1P5
受体，
EC50
分别为0.39 nM和0.98 nM，比作用于S1P2， S1P3和S1P4受体选择性高1000倍以上。 Phase 3。
CC2220
Balofloxacin
Balofloxacin是一种喹诺酮类抗生素，通过干扰DNA促旋酶，而抑制细菌DNA合成。
CC8897
BAY 61-3606
BAY 61-3606是高活性ATP竞争性，可逆的Syk选择性抑制剂，Ki为7.5 nM，对Btk，Fyn，Itk，Lyn和Src无抑制性。
CC3209
Azelnidipine
Azelnidipine是一种二氢吡啶类钙通道阻断剂。
CC8898
Takinib
Takinib 是一种有效且有选择性的 TAK1 抑制剂，其 IC50 值为 9.5 nM。
CC7465
BAY 87-2243
BAY 87-2243是一种有效的选择性
hypoxia-inducible factor-1 (HIF-1)
抑制剂。Phase 1。
CC8899
MBX-8025 (seladelpar)
Seladelpar, also known as MBX-8025 and RWJ-800025, is a selective peroxisome proliferator-activated receptor (SPPAR) -δ receptor agonist. MBX-8025 may have potential use for the treatment of dyslipidemia, metabolic syndrome, type 2 diabetes, and non-alcoh
CC9002
BMS-986205
BMS-986205 is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
CC8080
Bay K 8644
Bay K 6244是一种高选择性的L型钙离子通道激动剂，EC50为17.3 nM。
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