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商品列表
显示方式:
Cat#
产品名称
信息描述
CC7835
YK-4-279
YK-4-279是
EWS-FLI1
与
RNA helicase A (RHA)
结合的有效抑制剂。
CC7411
NMS-P937 (NMS1286937)
NMS-P937(NMS1286937)是一种口服有效的,选择性
Polo-like Kinase 1 (PLK1)
抑制剂有,其
IC50
为2 nM,比PLK2/PLK3高出5000倍的选择性。第1阶段。
CC7903
Ro-3306
RO-3306是一种ATP竞争性的选择性
CDK1
抑制剂,
K
i
为20 nM,选择性是其他各种人类激酶的15倍多。
CC7488
K-Ras(G12C) inhibitor 9
K-Ras(G12C) inhibitor 9 是致癌的
K-Ras(G12C)
的变构抑制剂。
CC8905
MBQ-167
MBQ-167是一种有效的
Rac
和
Cdc42
双重抑制剂,在转移性乳腺癌细胞中,IC50分别为103 nM和78 nM。
CC2924
Dinaciclib (SCH727965)
Dinaciclib (SCH727965)是一种新型有效的CDK抑制剂,作用于
CDK2
,
CDK5
,
CDK1
和
CDK9
,无细胞试验中
IC50
分别为1 nM,1 nM,3 nM和4 nM。它也会阻断胸甘(dThd) DNA整合。Phase 3。
CC7449
ZCL278
ZCL278是一个选择性的Cdc42 GTP酶抑制剂,Kd为11.4 μM。
CC2875
AMG-900
AMG-900是一种有效的,高选择性的pan-
Aurora kinases
抑制剂,作用于Aurora A/B/C,
IC50
为5 nM/4 nM/1 nM,作用于Aurora激酶比作用于p38α, Tyk2, JNK2, Met和Tie2选择性高10倍以上。Phase 1。
CC8187
NSC 23766
NSC 23766是一种
Rac GTPase
抑制剂,通过鸟嘌呤核苷酸因子(GEFs)靶向作用于Rac 活化,无细胞试验中
IC50
为~50 μM;但是不会抑制密切相关的靶点,Cdc42或RhoA。
CC7404
Ro3280
Ro3280是一种有效的,高选择性
Polo-like kinase 1(PLK1)
抑制剂,
IC50
为3 nM。
总计
146
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